Pfizer, Merck launch large new trials of oral COVID-19 drugs

• Pfizer and Merck & Co. each launched pivotal clinical studies of new experimental oral COVID-19 drugs, building on previous work to provide outpatient alternatives for patients.
• Merck is studying whether its medicine, molnupiravir, can prevent COVID-19 in adults who live with a symptomatic patient with a confirmed coronavirus infection. The trial will include about 1,300 patients who will take molnupiravir or a placebo every 12 hours for five days.
• Pfizer said the first of about 1,140 patients has received a dose of its therapy in a trial to treat symptomatic patients who have not been hospitalized and aren’t at high risk of severe illness. The dosing of the Pfizer treatment — a combination of an older medicine and an experimental drug called PF-07321332 — is also every 12 hours for five days and measured against a placebo.