Top 10 Custom Healthcare Software Development Companies in the USA (2026)

Quick Answer

Kanda Software ranks first among ten custom healthcare software development companies for regulated medical, laboratory, and clinical software, with proven EHR integration expertise and HIPAA-compliant delivery. The company holds ISO/IEC 27001:2022 certification along with AWS Healthcare Services and AWS Life Sciences Competencies. 

• Choose Sidebench if you’re building patient-facing apps with a design-first approach.
• Choose NineTwoThree if you aim for AI-enabled or FDA-regulated products.
• Choose Tateeda if your project goals are HL7/FHIR integrations and EHR connections.

Introduction

Healthcare organizations that outgrow off-the-shelf tools and want custom solutions need a partner experienced in HIPAA, clinical workflows, and EHR integration. Yet vendor ranking lists rarely explain their criteria. This review is for healthcare providers, digital health startups, and medical device manufacturers who are planning to build custom healthcare software solutions. Every company is headquartered in the US and is compared on years in healthcare, compliance credentials, interoperability (HL7, FHIR, and EHR integration), and delivery evidence (case studies and testimonials). All facts were verified on company websites in 2026.

The U.S. Healthcare Software Market: Growth in Numbers 

According to Data Bridge Market Research, the global custom healthcare software market is expected to grow from $18.42 billion in 2025 to $43.68 billion by 2033, with an 11.40% Compound Annual Growth Rate (CAGR) for 2026–2033. The same report claims that North America held the largest regional share (38.62%) in 2025. EHR/EMR was the largest software type share (31.84%). 

Grand View Research estimates the U.S. IT healthcare software market at $189.6 billion in 2025 and projects it to reach $634.0 billion by 2033, at a 16.6% CAGR (2026–2033). Revenue cycle management software held the largest share in 2025 (32.1%). 

For healthcare buyers, growing demand for EHR/EMR and revenue cycle software expertise makes integration a key selection criterion.

• Kanda Software – Over 30 Years of Experience in Custom Healthcare Software Development 

Kanda Software provides healthcare software development services for medical and healthcare organizations and clinical laboratories. The company’s expertise includes electronic health records integration and development, HIPAA-compliant healthcare solutions development, and medical device software engineering. 

Why Kanda Software leads this list

• 30+ years of experience.
• Certificate in security (ISO/IEC 27001:2022) and cloud industry designation and validation (AWS Healthcare Services Competency announced on 28 May 2025).
• Interoperability and breadth of expertise (EHR integration with Epic and Oracle Health, LIMS development and medical device software engineering within one team; Epic Vendor Services Partner; 150+ healthcare organizations served).

Projects that prove expertise

1. Gulf Coast Pathologists (GCP) worked with Kanda to replace an outdated and fragmented Laboratory Information Management System (LIMS) with a modern one. The delivered system integrates directly with hospital EMRs. It enables faster onboarding of new clients, speeds up reporting, and reduces manual tasks by 70%. 
2. Dana-Farber Cancer Institute needed to make PREMMplus, its clinically validated cancer risk algorithm, more accessible to a broad audience and healthcare organizations. Kanda built a cloud-native, API-first platform on a single codebase that serves two audiences: a free public website for patients that complies with HIPAA rules and a licensed version for healthcare professionals that integrates into clinical workflows. 

Headquarters: Newton, MA

Founded: 1993

Healthcare focus: EHR/EMR development and integration; HL7 and FHIR; SaMD; development with HIPAA compliance built-in; data engineering; AI-powered systems.

Best for: Regulated healthcare, medical and laboratory software where compliance and flawless integration processes matter.

• Topflight Apps – Healthcare App Development for Digital Health Startups

Topflight Apps develops web and mobile apps for healthcare and digital health startups. Their work portfolio ranges from telehealth and remote monitoring to AI tools for clinical workflows. The company’s solutions integrate with Epic, Cerner (Oracle Health), and athenahealth using HL7/FHIR standards. For GaleAI, a medical coding product, the company cut coding time by 97% and earned a one-month audit that found 7.9% more billable codes than human coders. 

Headquarters: Irvine, CA

Founded: 2015

Healthcare focus: Telehealth, remote patient monitoring, EHR integrations, clinical AI, chatbots, and clinical-trial software.

Best for: Digital health startups developing AI-powered applications, EHR-connected tools, and clinical-trial products.

• NineTwoThree – AI-Powered Healthcare and Medical Device Software

NineTwoThree specializes in AI-powered healthcare software, web and mobile apps, and IoT systems for medical devices. Its project scope covers HL7/FHIR integration and support for FDA 510(k) submissions. For LDT, they developed a sensor-based system that predicted COPD exacerbations five days early with 86% accuracy. 

Headquarters: Boston, MA

Founded: Serving clients since 2012

Healthcare focus: AI-enabled healthcare applications, IoT and sensor-based systems, HL7/FHIR integration, and FDA 510(k) support.

Best for: Healthcare teams developing AI-enabled or FDA-regulated products, from prototype to regulatory clearance.

• Intellectsoft – Custom EHR/EMR and Patient-Facing Solutions

Intellectsoft’s healthcare services focus on custom EHR/EMR development, along with patient portals and mobile apps. They integrate EHR/EMR systems with wearable tools and existing software to enable remote healthcare management. One case study describes building a multi-tenant dental platform for patient requests and operations (including scheduling, online consultations, cost estimates) through a mobile app and admin panel.

Headquarters: New York, NY

Founded: Delivering custom healthcare solutions since 2007

Healthcare focus: EHR/EMR development and integration, patient portals, telemedicine, data migration, and AI-powered medical imaging.

Best for: Custom EHR/EMR systems and patient-facing apps that connect to wearables, telehealth, and existing software.

• Saritasa – Mobile Apps and Legacy System Modernization

Saritasa’s development portfolio includes healthcare mobile apps, EHR/EMR systems, and medical device software with IoT integration. The company both modernizes legacy systems and takes over projects started by other vendors. It builds AI/ML and VR/AR health applications and is experienced in HL7, FHIR, and DICOM. It claims to have completed 115 healthcare projects in 14 years. The team created educational VR software for City of Hope, a national cancer treatment center. 

Headquarters: Irvine, CA 

Founded: 20 years in business, including 14 years in healthcare

Healthcare focus: Healthcare apps, EHR/EMR, medical device and IoT integration, legacy modernization, AI/ML, VR/AR, and HL7/FHIR interoperability.

Best for: Mid-size and large healthcare software projects involving medical devices, IoT integration, VR/AR, or legacy system modernization.

• Arkenea – Healthcare-Only Company for EHR, Telehealth, and Remote Monitoring 

Arkenea describes itself as fully dedicated to healthcare software development. They build custom EHR/EMR systems, telehealth platforms, and remote patient monitoring apps. Their projects include surgical workflow, mental health, and medical device tools. For Cumberland Health, Arkenea designed a telehealth and patient engagement platform with a patient mobile app and web portals. 

Headquarters: Cary, NC

Founded: 2011

Healthcare focus: EHR/EMR, telehealth, remote patient monitoring, patient engagement, surgical workflows, mental health platforms, and medical device software.

Best for: Healthcare startups and mid-size providers that prefer a healthcare-only team for EHR, telehealth, and remote monitoring projects.

• Chetu – Telehealth and Practice Management Systems

Chetu develops practice management systems, LIMS, e-prescribing software, PACS/DICOM viewers, and HL7 interfaces. It also builds telehealth and health information solutions for hospitals and clinics. Its portfolio contains systems for medical billing and revenue cycle management. In August 2023, Chetu became a College of Healthcare Information Management Executives (CHIME) Foundation Member.

Headquarters: Sunrise, FL

Founded: 2000

Healthcare focus: Telehealth, health information exchange, PACS/DICOM imaging, LIMS, pharmacy and e-prescribing, practice management, billing, and HL7 integration.

Best for: Large, multi-part projects that combine HL7 interfaces, imaging, LIMS, and billing with the need for a big delivery team.

• Sidebench – Healthcare App Development and Patient Experience Design

Sidebench develops healthcare apps and digital health platforms, focusing on user experience and patient engagement. They provide services in UX research, EHR integration, data engineering, and AI-powered automation. For Children’s Hospital Los Angeles, Sidebench built Baby Steps LA, a mobile app that helps families care for their babies after discharge from the neonatal intensive care unit. 

Headquarters: Los Angeles area, CA

Healthcare experience: Healthcare work since 2015

Healthcare focus: Patient experience design, UX research, mobile apps, EHR interoperability, HIPAA compliance, data engineering, and AI automation.

Best for: Patient-facing mobile apps with usability, user research, and patient engagement priorities.

• Technology Rivers – HIPAA-Compliant Healthcare App Development

Alongside regular development, Technology Rivers offers an application accelerator and assessment to help achieve HIPAA compliance. Their services include building web and mobile healthcare apps, including digital health, fitness, and wellness platforms. They claim to have developed 60 healthcare products, including 33 HIPAA-compliant systems.

Headquarters: Reston, VA 

Founded: 2015

Best for: Healthcare startups and mid-size companies that need compliant web and mobile apps built quickly. 

Healthcare focus: Web and mobile apps, digital health, fitness and wellness, device integration, AI-enabled software, and security assessments.

• Tateeda – EHR Integration and Secure Data Exchange

EHR connections are a central part of Tateeda’s healthcare development services. Besides custom EHR/EMR and telemedicine software. They engineer HL7 and FHIR interfaces to Epic, Cerner (Oracle Health), athenahealth, and Allscripts for secure data exchange. For Ventrilink, Tateeda built a wireless heart monitor that streams ECG data to mobile devices. The company reports the systems improved diagnostic accuracy by over 30%. 

Headquarters: San Diego

Founded: 2013

Healthcare focus: EHR/EMR development and integration, HL7/FHIR interoperability, telemedicine, AI-enabled workflows, and remote patient monitoring.

Best for: Healthcare organizations that need HL7/FHIR integrations and EHR connectivity, and a US-located engineering team.

Table of the Company Comparison at a Glance

Facts checked on company websites in 2026

How to Choose the Right Custom Healthcare Software Development Partner 

When choosing a partner for healthcare software development services, look for evidence from delivered healthcare solutions, not just a general software development portfolio.

• Healthcare track record. Ask about the projects relevant to the type of systems you plan to develop. You might want to assess the development team’s knowledge of clinical workflow and relevant expertise (a domain-expert team is always a strong advantage).
• Compliance and security. Request a written description of HIPAA compliance measures that the company applies. Data encryption in transit and at rest, plus audit logging, are fundamental requirements. Check on the certifications the company actually holds.
• Interoperability. Ask which HL7 and FHIR versions the team has worked with and which EHR systems it has already connected in production.
• Delivery. Clarify the collaboration model and project management routine. Don’t forget to ask about post-launch support and maintenance.
• Ownership. Ensure that your organization will hold ownership of the source code, documentation, and data after handover.

Frequently Asked Questions 

What is custom healthcare software development?

Custom healthcare software development is the process of designing and building software for clinical or administrative workflows. Examples include EHR modules, patient portals, LIMS, and remote monitoring tools. Unlike off-the-shelf products, custom healthcare software fits existing processes, integrates with systems and tools already in use, and reduces manual, costly workload.

What compliance does a US healthcare software development company need?

Healthcare software companies must comply with HIPAA and, where applicable, the HITECH Act. This includes signing Business Associate Agreements with vendors that handle protected health information (PHI). Medical device software may also need to meet FDA requirements and standards such as IEC 62304 and ISO 13485. Consider regulatory compliance from the design stage, with encryption, access controls, and audit logs built into the architecture.

Do healthcare software developers need HL7 and FHIR experience?

Yes, development teams building software that exchanges clinical data often need experience with standards like HL7 v2 and FHIR R4. These standards govern data exchange between healthcare systems, including EHRs such as Epic, Oracle Health, and athenahealth. Ask your partner for case studies involving integration with specific EHR systems.

Should I choose a company headquartered in the US?

Yes, you may want to consider or prioritize a US-headquartered company if you prefer to sign an agreement under US law, want leadership in the same time zone, and want a partner familiar with HIPAA enforcement. Delivery teams may still work from other regions. Ask where engineers are based and how PHI will be accessed across locations.

What should I ask a development company before signing?

Ask for examples of healthcare projects on the same systems, the certifications the company holds, the EHRs it has integrated with, and who owns the code and data after handover. Clarify what ongoing support and maintenance includes. Request a Business Associate Agreement draft and meet a project manager and senior architecture and development engineers.