Efficacy, Appropriateness of Antibiotic Use in the ICU

The frequency of antibiotic-resistant pathogens continues to increase, resulting in higher community-acquired infections and high mortality rates in criti...

The frequency of antibiotic-resistant pathogens continues to increase, resulting in higher community-acquired infections and high mortality rates in critically ill patients. In this review, the researchers critically appraise available evidence through a comprehensive literature review to investigate effective empiric antibiotic administration and appropriateness on outcomes of critically ill patients who are at a higher risk of developing resistant pathogens. The researchers contend that the use of new antibiotics should be based on relevant knowledge of their spectrum and properties to ensure they provide an effective mode of action in critically ill patients.