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Effect of Digital Adherence Technologies on Treatment Outcomes in People with Drug-Susceptible Tuberculosis: four Pragmatic, Cluster-Randomised Trials
A study evaluating digital adherence technologies in tuberculosis treatment found no significant improvement in patient outcomes across four countries. Conducted as cluster-randomized trials in the Philippines, South Africa, Tanzania, and Ukraine, the research assessed smart pillboxes and medication labels against standard care. Among 23,483 participants analyzed, the intervention did not significantly reduce treatment failure, loss to follow-up, or mortality. While adherence monitoring was achieved, concerns arose regarding patient privacy, leading to withdrawals. The findings suggest that digital adherence tools should not be broadly implemented without further economic evaluation and stakeholder input. The study highlights the need for comprehensive assessment beyond programmatic outcomes to determine the true value of digital health interventions in tuberculosis care.
Medigy Insights
A cluster-randomized study across four countries assessed digital adherence technologies in tuberculosis treatment but found no significant improvement in outcomes. Among 23,483 participants, smart pillboxes and medication labels did not reduce treatment failure, loss to follow-up, or mortality compared to standard care. Privacy concerns led to some patient withdrawals. While adherence monitoring was achieved, the study emphasizes the need for further economic evaluation and stakeholder input before widespread implementation. Future research should consider broader patient-centered outcomes to assess the true value of digital adherence tools in tuberculosis care.
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